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Article

Loss‐of‐function mutations in filaggrin gene and malignant melanoma: a case–control study

22 Aug 2017

Abstract excerpt

BACKGROUND: Loss-of-function mutations in filaggrin gene (FLG) have been suggested to increase the susceptibility of skin malignancies due to reduced levels of epidermal filaggrin and its degradation products, urocanic acid, which may be protective against ultraviolet irradiation. OBJECTIVE: We aimed to investigate the association between FLG mutation status and the occurrence of malignant melanoma (MM) in Danish...

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Share to Cutaneous Melanoma Detection and Management
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PMID: 28833578
DOI: 10.1111/jdv.14532

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