Article
Filaggrin loss-of-function mutations and incident cancer: a population-based study.
The British journal of dermatology - 1 Dec 2014
Skaaby T, Husemoen L L N, Thyssen J P, Meldgaard M, Thuesen B H, Pisinger C, Jørgensen T, Carlsen K, Johansen J D, Menné T, Szecsi P B, Stender S, Linneberg A
Abstract excerpt
BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG) could have opposing effects on cancer risk, as mutations are associated with both 10% higher serum vitamin D levels, which may protect against cancer, and with impaired skin barrier function, which may lead to higher cancer susceptibility. OBJECTIVES: To investigate the association of the FLG genotype and cancer types in four population-based...
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