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Article

Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1.

The Journal of cell biology - 4 Jun 2007

Wolfe Breann L, Marchese Adriano, Trejo JoAnn

Abstract excerpt

Protease-activated receptor-1 (PAR1), a G protein-coupled receptor (GPCR) for thrombin, is irreversibly activated by proteolysis. Consequently, PAR1 trafficking is critical for the fidelity of thrombin signaling. PAR1 displays constitutive and agonist-induced internalization, which are clathrin a...

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Identifiers

PMID: 17535965
DOI: 10.1083/jcb.200610154
PMCID: PMC2064289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17535965-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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