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Article

PI3K/Akt and GSK-3β prevents in a differential fashion the malignant phenotype of colorectal cancer cells.

Journal of cancer research and clinical oncology - 1 Nov 2010

de Araújo Wallace Martins, Vidal Flavia Castello Branco, de Souza Waldemir Fernandes, de Freitas Julio César Madureira, de Souza Wanderley, Morgado-Diaz Jose Andres

Abstract excerpt

PURPOSE: During colorectal cancer progression, the loss of differentiation and cell-cell adhesion as well as a higher migratory potential are well-defined features; however, the signaling mechanism governing these events is not fully elucidated. The aim of this study was to investigate the role that PI3K and downstream effectors play in controlling colon cancer malignant phenotypes. METHODS: HCT-116 cells, a...

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PMID: 20204404
DOI: 10.1007/s00432-010-0836-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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