Article

A Paracrine-to-Autocrine Shunt of GREM1 Fuels Colorectal Cancer Metastasis via ACVR1C

2025-09-17

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Tumor cells typically rely on paracrine stromal signals to guide malignant behavior, yet whether they gain signaling autonomy and thereby reduce microenvironment dependency during metastasis remains unclear. <bold>Methods:</bold> Colorectal cancer (CRC) specimens from stages I–IV were analyzed by immunohistochemistry and single-cell transcriptomics to asses...

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Literature Corpus work: a2cbcf76-2830-5a21-aa02-a0b6c78f2496
DOI: 10.21203/rs.3.rs-7484753/v1

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