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Article

Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR-200 levels in extracellular vesicles.

Journal of extracellular vesicles - 1 May 2022

Bhome Rahul, Emaduddin Muhammad, James Victoria, House Louise M, Thirdborough Stephen M, Mellone Massimiliano, Tulkens Joeri, Primrose John N, Thomas Gareth J, De Wever Olivier, Mirnezami Alex H, Sayan A Emre

Abstract excerpt

Colorectal cancer (CRC) with a mesenchymal gene expression signature has the greatest propensity for distant metastasis and is characterised by the accumulation of cancer-associated fibroblasts in the stroma. We investigated whether the epithelial to mesenchymal transition status of CRC cells influences fibroblast phenotype, with a focus on the transfer of extracellular vesicles (EVs), as a controlled means of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35595718
DOI: 10.1002/jev2.12226
PMCID: PMC9122835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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