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Protein Kinase B/AKT and Focal Adhesion Kinase: Two Close Signaling Partners in Cancer

1 Dec 2011

Abstract excerpt

AKT (or protein kinase B) and focal adhesion kinase (FAK) are two important kinases that regulate various cellular functions. Each is overexpressed and/or aberrantly activated in diverse cancers. Several small molecular inhibitors targeting either AKT or FAK are in development or in clinical trials. It is well established that FAK is an upstream regulator of AKT signaling pathway in various cancer cell lines and...

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PMID: 22023045
DOI: 10.2174/187152011797927661

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