High-resolution hepatitis C virus subtyping using NS5B deep sequencing and phylogeny, an alternative to current methods.

doi:10.1128/JCM.02093-14

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Article

High-resolution hepatitis C virus subtyping using NS5B deep sequencing and phylogeny, an alternative to current methods.

Journal of clinical microbiology - 1 Jan 2015

Quer Josep, Gregori Josep, Rodríguez-Frias Francisco, Buti Maria, Madejon Antonio, Perez-del-Pulgar Sofia, Garcia-Cehic Damir, Casillas Rosario, Blasi Maria, Homs Maria, Tabernero David, Alvarez-Tejado Miguel, Muñoz Jose Manuel, Cubero Maria, Caballero Andrea, del Campo Jose Antonio, Domingo Esteban, Belmonte Irene, Nieto Leonardo, Lens Sabela, Muñoz-de-Rueda Paloma, Sanz-Cameno Paloma, Sauleda Silvia, Bes Marta, Gomez Jordi, Briones Carlos, Perales Celia, Sheldon Julie, Castells Lluis, Viladomiu Lluis, Salmeron Javier, Ruiz-Extremera Angela, Quiles-Pérez Rosa, Moreno-Otero Ricardo, López-Rodríguez Rosario, Allende Helena, Romero-Gómez Manuel, Guardia Jaume, Esteban Rafael, Garcia-Samaniego Javier, Forns Xavier, Esteban Juan Ignacio

Abstract excerpt

Hepatitis C virus (HCV) is classified into seven major genotypes and 67 subtypes. Recent studies have shown that in HCV genotype 1-infected patients, response rates to regimens containing direct-acting antivirals (DAAs) are subtype dependent. Currently available genotyping methods have limited subtyping accuracy. We have evaluated the performance of a deep-sequencing-based HCV subtyping assay, developed for the...

Topics

Genotype
Genotyping Techniques
Hepacivirus
Hepatitis C
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Phylogeny

Reagent Kits, Diagnostic

Viral Nonstructural Proteins

Source

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Identifiers

PMID: 25378574
DOI: 10.1128/JCM.02093-14
PMCID: PMC4290919

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