Article
Whole genome pyrosequencing of rare hepatitis C virus genotypes enhances subtype classification and identification of naturally occurring drug resistance variants.
The Journal of infectious diseases - 1 Jul 2013
Newman Ruchi M, Kuntzen Thomas, Weiner Brian, Berical Andrew, Charlebois Patrick, Kuiken Carla, Murphy Donald G, Simmonds Peter, Bennett Phil, Lennon Niall J, Birren Bruce W, Zody Michael C, Allen Todd M, Henn Matthew R
Abstract excerpt
BACKGROUND: Infection with hepatitis C virus (HCV) is a burgeoning worldwide public health problem, with 170 million infected individuals and an estimated 20 million deaths in the coming decades. While 6 main genotypes generally distinguish the global geographic diversity of HCV, a multitude of closely related subtypes within these genotypes are poorly defined and may influence clinical outcome and treatment...
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