Article
Global epidemiology of HCV subtypes and resistance-associated substitutions evaluated by sequencing-based subtype analyses.
Journal of hepatology - 1 Aug 2017
Welzel Tania M, Bhardwaj Neeru, Hedskog Charlotte, Chodavarapu Krishna, Camus Gregory, McNally John, Brainard Diana, Miller Michael D, Mo Hongmei, Svarovskaia Evguenia, Jacobson Ira, Zeuzem Stefan, Agarwal Kosh
Abstract excerpt
BACKGROUND & AIMS: HCV genotype, subtype, and presence of resistance-associated substitutions (RASs) are key determinants for the selection of direct-acting antiviral (DAA) treatment regimens. However, current HCV genotyping assays have limitations in differentiating between HCV subtypes, and RAS prevalence is largely undefined. The aim of this study was to investigate HCV epidemiology in 12,615 patient samples...
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