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Article

NS3 genomic sequencing and phylogenetic analysis as alternative to a commercially available assay to reliably determine hepatitis C virus subtypes 1a and 1b.

PloS one - 1 Jan 2017

Neukam Karin, Martínez Alfredo P, Culasso Andrés C A, Ridruejo Ezequiel, García Gabriel, Di Lello Federico A

Abstract excerpt

OBJECTIVE: To evaluate the use of hepatitis C virus (HCV) NS3 sequencing as alternative to the comercially available Versant HCV 2.0 reverse hybridization line-probe assay (LiPA 2.0) to determine HCV genotype 1 (HCV-1) subtypes. PATIENTS AND METHODS: A cohort of 104 patients infected by HCV-1 according to LiPA 2.0 was analyzed in a cross-sectional study conducted in patients seen from January 2012 to June 2016 at...

Topics

Argentina
Cross-Sectional Studies
Genome, Viral
Genotype
Hepacivirus
Hepatitis C
Phylogeny
Viral Nonstructural Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28753662
DOI: 10.1371/journal.pone.0182193
PMCID: PMC5533332

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