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Article

Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-αVβ3 integrin cross talk.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2015

Wu Jianbo, Strawn Tammy L, Luo Mao, Wang Liqun, Li Rong, Ren Meiping, Xia Jiyi, Zhang Zhuo, Ma Weizhong, Luo Tingting, Lawrence Daniel A, Fay William P

Abstract excerpt

OBJECTIVE: Plasminogen activator inhibitor-1 (PAI-1) regulates angiogenesis via effects on extracellular matrix proteolysis and cell adhesion. However, no previous study has implicated PAI-1 in controlling vascular endothelial growth factor (VEGF) signaling. We tested the hypothesis that PAI-1 downregulates VEGF receptor-2 (VEGFR-2) activation by inhibiting a vitronectin-dependent cooperative binding interaction...

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Identifiers

PMID: 25378411
DOI: 10.1161/ATVBAHA.114.304554
PMCID: PMC4270947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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