Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of pharmacologic plasminogen activator inhibitor-1 inhibition on cell motility and tumor angiogenesis.

Journal of thrombosis and haemostasis : JTH - 1 Dec 2006

Leik C E, Su E J, Nambi P, Crandall D L, Lawrence D A

Abstract excerpt

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) is integrally involved in tumorigenesis by impacting on both proteolytic activity and cell migration during angiogenesis. OBJECTIVES: We hypothesized that an orally active small molecule inhibitor of PAI-1 (PAI-039; tiplaxtinin) could affect smooth muscle cell (SMC) attachment and migration in vitro on a vitronectin matrix, and exhibit antiangiogenic activity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis Inhibitors
Share to Aorta
Share to Drug Combinations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Laminin

Share to Neovascularization, Pathologic

Share to Plasminogen Activator Inhibitor 1

Share to Proteoglycans

Share to Vitronectin

Source

Identifiers

PMID: 17010152
DOI: 10.1111/j.1538-7836.2006.02244.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of pharmacologic plasminogen activator inhibitor-1 inhibition on cell motility and tumor angiogenesis.PMID 17010152Read ↗

Pharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima Formation.Semantic proximity Read ↗

Wound-induced migration of MDA-MB-435 and SKOV-3 cancer cells is regulated by plasminogen activator inhibitor-1.Semantic proximity Read ↗

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin.Semantic proximity Read ↗

Historical analysis of PAI-1 from its discovery to its potential role in cell motility and diseaseSemantic proximity Read ↗

Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-αVβ3 integrin cross talk.Semantic proximity Read ↗

The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent.Semantic proximity Read ↗

Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent.Semantic proximity Read ↗

The vasostatin-1 fragment of chromogranin A preserves a quiescent phenotype in hypoxia-driven endothelial cells and regulates tumor neovascularization.Semantic proximity Read ↗

Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidateSemantic proximity Read ↗

Unexpected Role of Plasminogen Activator Inhibitor 1 in Cell Adhesion and DetachmentSemantic proximity Read ↗

Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1Semantic proximity Read ↗

Characterization of a small molecule PAI-1 inhibitor, ZK4044.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.