Article
Mapping of binding sites for heparin, plasminogen activator inhibitor-1, and plasminogen to vitronectin's heparin-binding region reveals a novel vitronectin-dependent feedback mechanism for the control of plasmin formation.
The Journal of biological chemistry - 15 Jun 1992
Kost C, Stüber W, Ehrlich H J, Pannekoek H, Preissner K T
Abstract excerpt
Vitronectin (VN) has been implicated as a major matrix-associated regulator component of plasminogen activation by serving as a potent stabilizing cofactor of plasminogen activator inhibitor-1 (PAI-1). The direct binding of heparin, plasminogen as well as PAI-1 in its latent and active form to im...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Binding Sites
- Cells, Cultured
- Endothelium, Vascular
- Extracellular Matrix
- Fibrinolysin
- Glycoproteins
- Heparin
- Humans
- Hydrolysis
- Molecular Sequence Data
- Mutation
- Peptides
- Plasminogen