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Article

Pharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima Formation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2016

Ji Yan, Weng Zhen, Fish Philip, Goyal Neha, Luo Mao, Myears Samantha P, Strawn Tammy L, Chandrasekar Bysani, Wu Jianbo, Fay William P

Abstract excerpt

OBJECTIVE: Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor that promotes and inhibits cell migration, plays a complex and important role in adverse vascular remodeling. Little is known about the effects of pharmacological PAI-1 inhibitors, an emerging drug class, on migration of vascular smooth muscle cells (SMCs) and endothelial cells (ECs), crucial mediators of vascular remodeling. We...

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Identifiers

PMID: 27659097
DOI: 10.1161/ATVBAHA.116.308344
PMCID: PMC5102271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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