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Article

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

17 May 2019

Abstract excerpt

Angiopoietins 1-4 (Ang1-4) represent an important family of growth factors, whose activities are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized are angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2). Ang1 is a potent angiogenic growth factor signaling through Tie2, whereas Ang2 was initially identified as a vascular disruptive agent with antagonistic activity through the same...

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PMID: 31108880
DOI: 10.3390/cells8050471

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