Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A critical role for non-coding RNA <i>GAS5</i> in growth arrest and rapamycin inhibition in human T-lymphocytes

22 Mar 2011

Abstract excerpt

Non-coding RNA GAS5 (growth arrest-specific transcript 5) is a 5'-TOP (5'-terminal oligopyrimidine tract) RNA, whose translation, and consequently also stability, is controlled by the mTOR (mammalian target of rapamycin) pathway. GAS5 was identified by functional expression cloning and is necessary and sufficient for normal growth arrest in both leukaemic and untransformed human T-lymphocytes. GAS5 is also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Cytokine Signaling Pathways and Interactions
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21428924
DOI: 10.1042/bst0390482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A critical role for non-coding RNA <i>GAS5</i> in growth arrest and rapamycin inhibition in human T-lymphocytesPMID 21428924Read ↗

Oncogenic Function of Growth Arrest-specific Transcript 5 by Competing with miR-423-3p to Regulate SMARCA4 in Hepatocellular CarcinomaSemantic proximity Read ↗

Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 ( GAS5 )Semantic proximity Read ↗

Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.Semantic proximity Read ↗

Role of the Long Non‐Coding RNA Growth Arrest‐Specific 5 in Glucocorticoid Response in Children with Inflammatory Bowel DiseaseSemantic proximity Read ↗

The long non-coding RNA GAS5 differentially regulates cell cycle arrest and apoptosis through activation of BRCA1 and p53 in human neuroblastoma.Semantic proximity Read ↗

Ribosomal protein L5 (RPL5/uL18) I60V mutation is associated to increased translation and modulates drug sensitivity in T-cell acute lymphoblastic leukemia cellsSemantic proximity Read ↗

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsSemantic proximity Read ↗

Long non-coding RNA growth arrest specific transcript 5 acts as a tumour suppressor in colorectal cancer by inhibiting interleukin-10 and vascular endothelial growth factor expressionSemantic proximity Read ↗

Ribosomal protein S6 is highly expressed in non-Hodgkin lymphoma and associates with mRNA containing a 5' terminal oligopyrimidine tract.Semantic proximity Read ↗

Ribosomal protein L5 (RPL5/uL18) I60V mutation is associated to increased translation and modulates drug sensitivity in T-cell acute lymphoblastic leukemia cells.Semantic proximity Read ↗

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6kSemantic proximity Read ↗

mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.