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Article

Associating cancer-related RNA structure disrupting SNPs in LincRNAs to function.

BMC genomics - 12 Dec 2025

Han Xueer, Anthon Christian, Geissler Adrian Sven, Sabarinathan Radhakrishnan, Seemann Stefan Ernst, Havgaard Jakob Hull, Gorodkin Jan

Abstract excerpt

BACKGROUND: Long intergenic non-coding RNAs (lincRNAs) and single nucleotide polymorphisms (SNPs) have been associated with cancers for years, yet the molecular mechanism is mostly unclear. The secondary structure of lincRNAs is often crucial for their biological function but can be disrupted by SNPs. However, only a small number of studies investigated how lincRNAs function through secondary structure. Given...

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PMID: 41387767
DOI: 10.1186/s12864-025-12226-0
PMCID: PMC12701586

Genes

IGF2BP2

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