Article

Introns encode a vast class of Kink-loop RNAs that autoregulate pre-mRNA splicing

2026-08-04

Abstract excerpt

Introns occupy nearly one-third of the human genome, yet whether they encode widespread regulatory functions remains unclear. Here, we identify a pervasive class of intron-derived Kink-loop RNAs (klRNAs) that locally control pre-mRNA processing. Using complementary enrichment strategies, we uncovered approximately 15,200 and 3,500 previously unannotated klRNAs in humans and mice, respectively. Bound by the conserv...

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Literature Corpus work: f45713ee-ea94-5b45-ba22-0414f24336ff
DOI: 10.64898/2026.08.03.742641

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