Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS.

doi:10.1038/s41467-020-18411-x

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Article

Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS.

Nature communications - 21 Sept 2020

Wu Xue, Niculite Cristina M, Preda Mihai Bogdan, Rossi Annalisa, Tebaldi Toma, Butoi Elena, White Mattie K, Tudoran Oana M, Petrusca Daniela N, Jannasch Amber S, Bone William P, Zong Xingyue, Fang Fang, Burlacu Alexandrina, Paulsen Michelle T, Hancock Brad A, Sandusky George E, Mitra Sumegha, Fishel Melissa L, Buechlein Aaron, Ivan Cristina, Oikonomopoulos Spyros, Gorospe Myriam, Mosley Amber, Radovich Milan, Davé Utpal P, Ragoussis Jiannis, Nephew Kenneth P, Mari Bernard, McIntyre Alan, Konig Heiko, Ljungman Mats, Cousminer Diana L, Macchi Paolo, Ivan Mircea

Abstract excerpt

We hereby provide the initial portrait of lincNORS, a spliced lincRNA generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem. While inducible by low O2 in a variety of cells and associated with hypoxia in vivo, our studies show that lincNORS is subject to multiple regulatory inputs, including estrogen signals. Biochemically, this lincRNA fine-tunes cellular...

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PMID: 32958772
DOI: 10.1038/s41467-020-18411-x
PMCID: PMC7505984

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