Article
FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.
Neuron - 22 Oct 2014
Seiradake Elena, del Toro Daniel, Nagel Daniel, Cop Florian, Härtl Ricarda, Ruff Tobias, Seyit-Bremer Gönül, Harlos Karl, Border Ellen Clare, Acker-Palmer Amparo, Jones E Yvonne, Klein Rüdiger
Abstract excerpt
FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to reveal the distinct structural bases for FLRT-mediated cell adhesion and repulsion in neurons. We...
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