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Article

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.

Structure (London, England : 1993) - 1 Sept 2015

Lu Yue C, Nazarko Olha V, Sando Richard, Salzman Gabriel S, Li Nan-Sheng, Südhof Thomas C, Araç Demet

Abstract excerpt

Fibronectin leucine-rich repeat transmembrane proteins (FLRTs) are cell-adhesion molecules with emerging functions in cortical development and synapse formation. Their extracellular regions interact with latrophilins (LPHNs) to mediate synapse development, and with Uncoordinated-5 (UNC5)/netrin receptors to control the migration of neurons in the developing cortex. Here, we present the crystal structures of FLRT3...

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Share to Cell Adhesion
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Glycoproteins

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Share to Receptors, Cell Surface

Share to Receptors, G-Protein-Coupled

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Source

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Identifiers

PMID: 26235030
DOI: 10.1016/j.str.2015.06.024
PMCID: PMC4851429

Genes

FLRT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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