Article
FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.
Current biology : CB - 3 Mar 2014
Leyva-Díaz Eduardo, del Toro Daniel, Menal Maria José, Cambray Serafi, Susín Rafael, Tessier-Lavigne Marc, Klein Rüdiger, Egea Joaquim, López-Bendito Guillermina
Abstract excerpt
BACKGROUND: Guidance molecules are normally presented to cells in an overlapping fashion; however, little is known about how their signals are integrated to control the formation of neural circuits. In the thalamocortical system, the topographical sorting of distinct axonal subpopulations relies on the emergent cooperation between Slit1 and Netrin-1 guidance cues presented by intermediate cellular targets....
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