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Article

Exploring genotype-phenotype correlations in three pediatric patients with IL10RA variants and very early-onset inflammatory bowel disease.

BMC gastroenterology - 28 Jan 2026

Qiu Rubiao, Zhang Mengxu, Li Tingting, Liang Yanping, Wang Yumei, Xu Songtao

Abstract excerpt

BACKGROUND: Very early onset inflammatory bowel disease (VEO-IBD) is a severe chronic intestinal inflammatory disorder with onset in infancy. Mutations in the interleukin-10 (IL-10) receptor A (IL10RA) gene represent a key pathogenic mechanism of VEO-IBD; however, the genotype–phenotype correlations remain unclear. OBJECTIVE: This study aims to describe and compare the clinical features, genotypes, and family...

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Age of Onset
Child
Child, Preschool
Genetic Association Studies
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inflammatory Bowel Diseases

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Open in PubMed Open full text

Identifiers

PMID: 41606474
DOI: 10.1186/s12876-026-04648-1
PMCID: PMC12922342

Genes

IL10RA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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