Article
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis.
Inflammatory bowel diseases - 1 Jan 2013
Moran Christopher J, Walters Thomas D, Guo Cong-Hui, Kugathasan Subra, Klein Christoph, Turner Dan, Wolters Victorien M, Bandsma Robert H, Mouzaki Marialena, Zachos Mary, Langer Jacob C, Cutz Ernest, Benseler Susanne M, Roifman Chaim M, Silverberg Mark S, Griffiths Anne M, Snapper Scott B, Muise Aleixo M
Abstract excerpt
BACKGROUND: Interleukin-10 (IL-10) signaling genes are attractive inflammatory bowel disease (IBD) candidate genes as IL-10 restricts intestinal inflammation, IL-10 polymorphisms have been associated with IBD in genome-wide association studies, and mutations in IL-10 and IL-10 receptor (IL-10R) genes have been reported in immunodeficient children with severe infantile-onset IBD. Our objective was to determine if...
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