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Article

High-throughput sequencing and copy number variation detection using formalin fixed embedded tissue in metastatic gastric cancer.

PloS one - 1 Jan 2014

Kim Seokhwi, Lee Jeeyun, Hong Min Eui, Do In-Gu, Kang So Young, Ha Sang Yun, Kim Seung Tae, Park Se Hoon, Kang Won Ki, Choi Min-Gew, Lee Jun Ho, Sohn Tae Sung, Bae Jae Moon, Kim Sung, Kim Duk-Hwan, Kim Kyoung-Mee

Abstract excerpt

In the era of targeted therapy, mutation profiling of cancer is a crucial aspect of making therapeutic decisions. To characterize cancer at a molecular level, the use of formalin-fixed paraffin-embedded tissue is important. We tested the Ion AmpliSeq Cancer Hotspot Panel v2 and nCounter Copy Number Variation Assay in 89 formalin-fixed paraffin-embedded gastric cancer samples to determine whether they are...

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Share to DNA Copy Number Variations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Metastasis

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Source

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Identifiers

PMID: 25372287
DOI: 10.1371/journal.pone.0111693
PMCID: PMC4221102

Genes

CCNE1
EGFR
KRAS
APC
MYC
SMAD4
SMO
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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