Article
High-throughput mutation profiling identifies frequent somatic mutations in advanced gastric adenocarcinoma.
PloS one - 1 Jan 2012
Lee Jeeyun, van Hummelen Paul, Go Christina, Palescandolo Emanuele, Jang Jiryeon, Park Ha Young, Kang So Young, Park Joon Oh, Kang Won Ki, MacConaill Laura, Kim Kyoung-Mee
Abstract excerpt
BACKGROUND: Gastric cancer is one of the leading cancer types in incidence and mortality, especially in Asia. In order to improve survival, identification of a catalogue of molecular alterations underlying gastric cancer is a critical step for developing and designing genome-directed therapies. METHODOLOGY/PRINCIPAL FINDINGS: The Center for Cancer Genome Discovery (CCGD) at the Dana-Farber Cancer Institute (DFCI)...
Topics
- Adenocarcinoma
- Adult
- Aged
- Class I Phosphatidylinositol 3-Kinases
- Female
- Genome-Wide Association Study
- Humans
- Male
- Middle Aged
- Mutation
- Mutation Rate