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Article

High-throughput mutation profiling identifies frequent somatic mutations in advanced gastric adenocarcinoma.

PloS one - 1 Jan 2012

Lee Jeeyun, van Hummelen Paul, Go Christina, Palescandolo Emanuele, Jang Jiryeon, Park Ha Young, Kang So Young, Park Joon Oh, Kang Won Ki, MacConaill Laura, Kim Kyoung-Mee

Abstract excerpt

BACKGROUND: Gastric cancer is one of the leading cancer types in incidence and mortality, especially in Asia. In order to improve survival, identification of a catalogue of molecular alterations underlying gastric cancer is a critical step for developing and designing genome-directed therapies. METHODOLOGY/PRINCIPAL FINDINGS: The Center for Cancer Genome Discovery (CCGD) at the Dana-Farber Cancer Institute (DFCI)...

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PMID: 22723903
DOI: 10.1371/journal.pone.0038892
PMCID: PMC3377730

Genes

CTNNB1
APC
STK11

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