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Article

Loss of function of SWI/SNF chromatin remodeling genes leads to genome instability of human lung cancer

3 Nov 2014

Abstract excerpt

SWI/SNF chromatin remodeling complexes are frequently mutated in a variety of human cancers. We investigated the mutation incidence and the role of mSWI/SNF (BAF) complexes in human lung cancer. In the present study, we analyzed somatic mutations of BAF complexes and other driver mutated genes of lung carcinoma deposited in the Catalogue of Somatic Mutations in Cancer (COSMIC) database. BAF complexes were mutated...

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PMID: 25370573
DOI: 10.3892/or.2014.3584

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