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Article

Exosomal NAMPT from chronic lymphocytic leukemia cells orchestrate monocyte survival and phenotype under endoplasmic reticulum stress.

Hematological oncology - 1 Feb 2023

Ni Jing, Zhang Ju, Liu Jiatao, Fan Lulu, Lin Xiao, Yu Hanqing, Sun Guoping

Abstract excerpt

Endoplasmic reticulum (ER) stress has been reported to be transmitted from tumor cells to immune cells via exosome and implicated in immune escape. However, the influence of ER stress on monocytes in chronic lymphocytic leukemia (CLL) cells is largely unknown. Here, we observed the expression of ER stress markers (GRP78, ATF6, PERK, IRE1a, and XBP1s) in CLL cells. The increasing mRNA expression of these ER stress...

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Identifiers

PMID: 36321597
DOI: 10.1002/hon.3093

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