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Article

Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors.

Oncotarget - 12 Jan 2016

Duarte-Pereira Sara, Pereira-Castro Isabel, Silva Sarah S, Correia Mariana Gonçalves, Neto Célia, da Costa Luís Teixeira, Amorim António, Silva Raquel M

Abstract excerpt

Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and a substrate for NAD-consuming enzymes, such as PARPs and sirtuins. As cancer cells have increased NAD requirements, the main NAD salvage enzymes in humans, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT), are involved in the development of novel anti-cancer therapies. Knowledge of the...

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Source

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Identifiers

PMID: 26675378
DOI: 10.18632/oncotarget.6538
PMCID: PMC4811510

Genes

NAPRT
NAMPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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