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Article

Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2015

Wen Luan, Fu Liezhen, Guo Xiaogang, Chen Yonglong, Shi Yun-Bo

Abstract excerpt

Histone methylations have been implicated to play important roles in diverse cellular processes. Of particular interest is the methylation of histone H3K79, which is catalyzed by an evolutionarily conserved methyltransferase, disruptor of telomeric silencing (Dot1)-like (Dot1L). To investigate th...

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Identifiers

PMID: 25366346
DOI: 10.1096/fj.14-252171
PMCID: PMC4314229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25366346-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis.PMID 25366346Read ↗

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.Semantic proximity Read ↗

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H3K79 methylation and H3K36 tri-methylation synergistically regulate gene expression in pluripotent stem cellsSemantic proximity Read ↗

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The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsivenessSemantic proximity Read ↗

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