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Article

Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice.

Bone - 1 Jan 2021

Sutter Pearl A, Karki Sangita, Crawley Ilan, Singh Vijender, Bernt Kathrin M, Rowe David W, Crocker Stephen J, Bayarsaihan Dashzeveg, Guzzo Rosa M

Abstract excerpt

Chromatin modifying enzymes play essential roles in skeletal development and bone maintenance, and deregulation of epigenetic mechanisms can lead to skeletal growth and malformation disorders. Here, we report a novel skeletal dysplasia phenotype in mice with conditional loss of Disruptor of telomeric silencing 1-like (Dot1L) histone methyltransferase in limb mesenchymal progenitors and downstream descendants....

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Identifiers

PMID: 33022452
DOI: 10.1016/j.bone.2020.115677
PMCID: PMC7744341

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