Article
Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2015
Jonnalagadda Mahesh, Mardiros Armen, Urak Ryan, Wang Xiuli, Hoffman Lauren J, Bernanke Alyssa, Chang Wen-Chung, Bretzlaff William, Starr Renate, Priceman Saul, Ostberg Julie R, Forman Stephen J, Brown Christine E
Abstract excerpt
The success of adoptive therapy using chimeric antigen receptor (CAR)-expressing T cells partly depends on optimal CAR design. CARs frequently incorporate a spacer/linker region based on the constant region of either IgG1 or IgG4 to connect extracellular ligand-binding with intracellular signaling domains. Here, we evaluated the potential for the IgG4-Fc linker to result in off-target interactions with Fc gamma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.