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Article

Hu8F4-CAR T cells with mutated Fc spacer segment improve target specificity and mediate anti-leukemia activity in vivo.

Cytotherapy - 1 Nov 2024

He Hong, Vedia Rolando A, Lu Sijie, Li Qiaochuan, Cox Kathryn R, St John Lisa, Sergeeva Anna, Clise-Dwyer Karen, Alatrash Gheath, Shpall Elizabeth J, Ma Qing, Molldrem Jeffrey J

Abstract excerpt

BACKGROUND AIMS: Hu8F4 is a T-cell receptor-like antibody with high affinity for the leukemia-associated antigen PR1/HLA-A2 epitope. Adapted into a chimeric antigen receptor (CAR) format, Hu8F4-CAR is composed of the Hu8F4 single-chain variable fragment, the human IgG1 CH2CH3 extracellular spacer domain, a human CD28 costimulatory domain and the human CD3ζ signaling domain. We have demonstrated high efficacy of...

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Share to HLA-A2 Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred NOD

Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 39033444
DOI: 10.1016/j.jcyt.2024.06.010
PMCID: PMC11471379

Genes

CD28

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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