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Article

A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes.

Frontiers in immunology - 1 Jan 2020

Schäfer Daniel, Henze Janina, Pfeifer Rita, Schleicher Anna, Brauner Janina, Mockel-Tenbrinck Nadine, Barth Carola, Gudert Daniela, Al Rawashdeh Wa'el, Johnston Ian C D, Hardt Olaf

Abstract excerpt

A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit highest activity on distal epitopes. This finding can be explained by the requirement to have an optimal distance...

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Identifiers

PMID: 32849600
DOI: 10.3389/fimmu.2020.01704
PMCID: PMC7426717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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