Article

Hu8F4-CAR T cells with mutated Fc spacer segment improve target-specificity and mediate anti-leukemia activity in vivo

2024-02-19

Abstract excerpt

<title>Abstract</title> <p>Hu8F4 is a T cell receptor (TCR)-like antibody with high affinity for leukemia-associated antigen PR1/HLA-A2 epitope. Adapted into a chimeric antigen receptor (CAR) format, Hu8F4-CAR is comprised of the Hu8F4 scFv, the human IgG1 CH2CH3 extracellular spacer domain, a human CD28 costimulatory domain, and the human CD3ζ signaling domain. We have demonstrated high efficacy of Hu8F4-CAR-T c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a15deafc-2075-549d-994f-9693a424693b
DOI: 10.21203/rs.3.rs-3937972/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hu8F4-CAR T cells with mutated Fc spacer segment improve target-specificity and mediate anti-leukemia activity in vivoDOI 10.21203/rs.3.rs-3937972/v1Read

Hu8F4-CAR T cells with mutated Fc spacer segment improve target specificity and mediate anti-leukemia activity in vivo.Semantic proximity Read

Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy.Semantic proximity Read

SRRM2 is a target for the immunotherapy of AML with rationally designed CAR-T cellsSemantic proximity Read

A CHIMERIC RECEPTOR ENABLING ANTIBODY-GUIDED RETARGETING OF CAR T- CELLSSemantic proximity Read

Pre-TCR-Targeted Immunotherapy for T-cell Acute Lymphoblastic LeukemiaSemantic proximity Read

A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes.Semantic proximity Read

Differential TIM-3 glycosylation enables specific dual targeting CAR-T therapy in acute myeloid leukemiaSemantic proximity Read

Characterization and Functional Analysis of scFv-based Chimeric Antigen Receptors to Redirect T Cells to IL13Rα2-positive GliomaSemantic proximity Read

VEGFR2-specific FnCAR effectively redirects the cytotoxic activity of T cells and YT NK cellsSemantic proximity Read

Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in Acute Myeloid LeukemiaSemantic proximity Read

TriLeukeVax: A CD80/IL-15/IL-15Rα Expressing Autologous AML Cell Vaccine Elicits Robust Anti-Leukemic Cytolytic ActivitySemantic proximity Read

A new universal chimeric-antigen receptor (CAR)- fragment antibody binder (FAB) split system for cancer immunotherapySemantic proximity Read