Article
Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions.
Cancer discovery - 1 Jan 2015
Liou Geou-Yarh, Döppler Heike, Necela Brian, Edenfield Brandy, Zhang Lizhi, Dawson David W, Storz Peter
Abstract excerpt
UNLABELLED: Desmoplasia and an inflammatory environment are defining features of pancreatic cancer. Unclear is how pancreatic cells that undergo oncogenic transformation can cross-talk with immune cells and how this contributes to the development of pancreatic lesions. Here, we demonstrate that pancreatic acinar cells expressing mutant KRAS can expedite their transformation to a duct-like phenotype by inducing...
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