Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease.

doi:10.1161/ATVBAHA.114.304729

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Article

Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2015

Pechlaner Raimund, Willeit Peter, Summerer Monika, Santer Peter, Egger Georg, Kronenberg Florian, Demetz Egon, Weiss Günter, Tsimikas Sotirios, Witztum Joseph L, Willeit Karin, Iglseder Bernhard, Paulweber Bernhard, Kedenko Lyudmyla, Haun Margot, Meisinger Christa, Gieger Christian, Müller-Nurasyid Martina, Peters Annette, Willeit Johann, Kiechl Stefan

Abstract excerpt

OBJECTIVE: The enzyme heme oxygenase-1 (HO-1) exerts cytoprotective effects in response to various cellular stressors. A variable number tandem repeat polymorphism in the HO-1 gene promoter region has previously been linked to cardiovascular disease. We examined this association prospectively in the general population. APPROACH AND RESULTS: Incidence of stroke, myocardial infarction, or vascular death was...

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Identifiers

PMID: 25359861
DOI: 10.1161/ATVBAHA.114.304729
PMCID: PMC4317265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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