Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans.

doi:10.1093/eurheartj/ehv544

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Article

Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans.

European heart journal - 21 Dec 2015

Wenzel Philip, Rossmann Heidi, Müller Christian, Kossmann Sabine, Oelze Matthias, Schulz Andreas, Arnold Natalie, Simsek Canan, Lagrange Jeremy, Klemz Roman, Schönfelder Tanja, Brandt Moritz, Karbach Susanne H, Knorr Maike, Finger Stefanie, Neukirch Carolin, Häuser Friederike, Beutel Manfred E, Kröller-Schön Swenja, Schulz Eberhard, Schnabel Renate B, Lackner Karl, Wild Philipp S, Zeller Tanja, Daiber Andreas, Blankenberg Stefan, Münzel Thomas

Abstract excerpt

AIMS: Heme oxygenase-1 (HO-1) confers protection to the vasculature and suppresses inflammatory properties of monocytes and macrophages. It is unclear how HO-1 determines the extent of vascular dysfunction in mice and humans. METHODS AND RESULTS: Decreased HO-1 activity and expression was paralleled by increased aortic expression and activity of the nicotinamide dinucleotide phosphate oxidase Nox2 in HO-1...

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PMID: 26516175
DOI: 10.1093/eurheartj/ehv544

Genes

HMOX1
CCR2

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