Article
Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: an observation based on arsenic-exposed individuals.
Atherosclerosis - 1 Dec 2011
Wu Meei-Maan, Chiou Hung-Yi, Chen Chi-Ling, Hsu Ling-I, Lien Li-Ming, Wang Chih-Hao, Hsieh Yi-Chen, Wang Yuan-Hung, Hsueh Yu-Mei, Lee Te-Chang, Cheng Wen-Fang, Chen Chien-Jen
Abstract excerpt
OBJECTIVE: Heme oxygenase (HO)-1 is up-regulated as a cellular defense responding to stressful stimuli in experimental studies. A GT-repeat length polymorphism in the HO-1 gene promoter was inversely correlated to HO-1 induction. Here, we reported the association of GT-repeat polymorphism with blood pressure (BP) phenotypes, and their interaction on cardiovascular (CV) mortality risk in arsenic-exposed cohorts....
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