Article
A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease.
Thrombosis and haemostasis - 1 Jan 2004
Endler Georg, Exner Markus, Schillinger Martin, Marculescu Rodrig, Sunder-Plassmann Raute, Raith Marianne, Jordanova Nelli, Wojta Johann, Mannhalter Christine, Wagner Oswald F, Huber Kurt
Abstract excerpt
Heme oxygenase 1 (HO-1) is involved in the generation of the endogenous anti-oxidant bilirubin which exerts beneficial effects against arteriosclerosis. A (GT) repeat polymorphism in the HO-1 promoter region modulates HO-1 expression in response to oxidative stress. Recently, this polymorphism has been reported to protect from coronary artery disease in Orientals. We intended to confirm this observation in...
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