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Article

A short PIWIL2 isoform PL2L60A induces functional and transcriptional changes indicative of a procancerous phenotype.

Molecular biology reports - 15 Nov 2025

Kondratieva Sofia, Skvortsova Yulia, Vishnyakova Polina, Grigorov Artem, Bychenko Oksana, Azhikina Tatyana

Abstract excerpt

BACKGROUND: RNA-binding PIWIL proteins are known as key contributors to germ cell development and stem cell maintenance, and deregulation of PIWIL expression is associated with various types of cancer. PIWIL2 is usually expressed in the testes, where it acts as a translational regulator and is considered a tumor-barrier protein. In contrast, short PIWIL2 isoforms transcribed from intragenic promoters are...

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Identifiers

PMID: 41240179
DOI: 10.1007/s11033-025-11259-8

Genes

PIWIL2

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