Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice.

The Journal of reproduction and development - 16 Feb 2017

Saito Takeshi, Hara Satoshi, Tamano Moe, Asahara Hiroshi, Takada Shuji

Abstract excerpt

Expression regulation of the Dlk1-Dio3 imprinted domain by the intergenic differentially methylated region (IG-DMR) is essential for normal embryonic development in mammals. In this study, we investigated conserved IG-DMR genomic sequences in eutherians to elucidate their role in genomic imprinting of the Dlk1-Dio3 domain. Using a comparative genomics approach, we identified three highly conserved sequences in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Binding Proteins
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Intergenic

Share to Genomic Imprinting

Share to Intercellular Signaling Peptides and Proteins

Share to Paternal Inheritance

Share to Protein Domains

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 27904015
DOI: 10.1262/jrd.2016-135
PMCID: PMC5320436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice.PMID 27904015Read ↗

Epigenome editing reveals core DNA methylation for imprinting control in the Dlk1-Dio3 imprinted domain.Semantic proximity Read ↗

A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonic development.Semantic proximity Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.Semantic proximity Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the <i>Dlk1-Dio3</i> locusSemantic proximity Read ↗

Efficient production and transmission of CRISPR/Cas9-mediated mutant alleles at the IG-DMR via generation of mosaic mice using a modified 2CC method.Semantic proximity Read ↗

Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice.Semantic proximity Read ↗

Genomic imprinting at the mammalian Dlk1-Dio3 domainSemantic proximity Read ↗

Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development.Semantic proximity Read ↗

The Evolution of the DLK1-DIO3 Imprinted Domain in MammalsSemantic proximity Read ↗

Protocol for DNA Methylation Editing of Imprinted Loci and Assessment of the Effects.Semantic proximity Read ↗

Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domainSemantic proximity Read ↗

Imprinting and expression analysis of a non-coding RNA gene in the mouse Dlk1-Dio3 domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.