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Article

Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage

10 Aug 2018

Abstract excerpt

The basic helix-loop-helix (bHLH) transcription factor ASCL2 plays essential roles in diploid multipotent trophoblast progenitors, intestinal stem cells, follicular T-helper cells, as well as during epidermal development and myogenesis. During early development, Ascl2 expression is regulated by genomic imprinting and only the maternally inherited allele is transcriptionally active in trophoblast. The paternal...

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PMID: 30096149
DOI: 10.1371/journal.pgen.1007587

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