Article

Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

2021-03-16

Abstract excerpt

Cytokine inducible SH2-containing protein (CISH) is a natural killer (NK) cell negative regulator of cytokine signaling pathway. To further understand CISH functions in NK cells, we developed a conditional Cish -deficient mouse model in NK cells ( Cish fl/fl Ncr1 Ki/+ ). We detected no developmental or homeostatic difference in NK cells. However, global gene expression of Cish fl/fl Ncr1 Ki/+ NK cells comp...

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Literature Corpus work: 6dd82f8c-2771-5631-89a1-09212a62a7d4
DOI: 10.1101/2021.03.16.435571

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