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Article

Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow Transplantation

15 Mar 2002

Abstract excerpt

Natural killer cell (NK) receptors for major histocompatibility complex (MHC) class I influence engraftment and graft-versus-tumor effects after allogeneic bone marrow transplantation. We find that SH2-containing inositol phosphatase (SHIP) influences the repertoire of NK receptors. In adult SHIP-/- mice, the NK compartment is dominated by cells that express two inhibitory receptors capable of binding either self...

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Identifiers

PMID: 11896280
DOI: 10.1126/science.1068438

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