Article
IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1.
The Journal of allergy and clinical immunology - 1 Jul 2007
Taylor Alison, Akdis Mübeccel, Joss Andrea, Akkoç Tunç, Wenig Renate, Colonna Marco, Daigle Isabelle, Flory Egbert, Blaser Kurt, Akdis Cezmi A
Abstract excerpt
BACKGROUND: Specific T-cell activation requires T-cell receptor stimulation and the generation of costimulatory signals. Major costimulatory signals are delivered to T cells by the interaction of CD28 and inducible costimulator (ICOS). OBJECTIVE: To investigate the molecular pathways involved in direct T-cell suppression by IL-10. METHODS: T-cell proliferation analysis, immunoprecipitations, and Western blots...
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