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Article

Expression inactivation of SMARCA4 by microRNAs in lung tumors

29 Oct 2014

Abstract excerpt

SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which alters the interactions between DNA and histones and modifies the availability of the DNA for transcription. The latest deep sequencing of tumor genomes has reinforced the important and ubiquitous tumor suppressor role of the SWI/SNF complex in cancer. However, although SWI/SNF complex plays a key role in gene expression, the...

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PMID: 25355421
DOI: 10.1093/hmg/ddu554

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