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Article

Polymorphisms influencing prostate-specific antigen concentration may bias genome-wide association studies on prostate cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2015

Dluzniewski Paul J, Xu Jianfeng, Ruczinski Ingo, Isaacs William B, Platz Elizabeth A

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have produced weak (OR = 1.1-1.5) but significant associations between single nucleotide polymorphisms (SNPs) and prostate cancer. However, these associations may be explained by detection bias caused by SNPs influencing PSA concentration. Thus, in a simulation study, we quantified the extent of bias in the association between a SNP and prostate cancer when the...

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PMID: 25352524
DOI: 10.1158/1055-9965.EPI-14-0863
PMCID: PMC4294961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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