Article
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.
Nature communications - 31 Jan 2017
Hoffmann Thomas J, Passarelli Michael N, Graff Rebecca E, Emami Nima C, Sakoda Lori C, Jorgenson Eric, Habel Laurel A, Shan Jun, Ranatunga Dilrini K, Quesenberry Charles P, Chao Chun R, Ghai Nirupa R, Aaronson David, Presti Joseph, Nordström Tobias, Wang Zhaoming, Berndt Sonja I, Chanock Stephen J, Mosley Jonathan D, Klein Robert J, Middha Mridu, Lilja Hans, Melander Olle, Kvale Mark N, Kwok Pui-Yan, Schaefer Catherine, Risch Neil, Van Den Eeden Stephen K, Witte John S
Abstract excerpt
Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa-such as genetics-can impact PSA. Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant (P<5 × 10-8) single-nucleotide polymorphisms...
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